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KMID : 0387820220290020089
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Clinical Pediatric Hematology-Oncology
2022 Volume.29 No. 2 p.89 ~ p.91
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A Case of B-cell Precursor Acute Lymphoblastic Leukemia with the t(14;22)(q32;q11) Presenting Hyperleukocytosis
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Lee Jianne
Kim Sun-Young
Lim Yeon Jung
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Abstract
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B-cell precursor acute lymphoblastic leukemia (BCP-ALL), which is the most common type of ALL, has an excellent prognosis with long-term event-free survival of 90%. The malignancy has several genetic abnormalities that may influence patient prog-nosis. Rearrangements of the three immunoglobulin genes IGK (2p12), IGH (14q32), and IGL (22q11) are often seen, especially in non-Hodgkin lymphoma (NHL), but re-combination of these genes are uncommon. The translocation, t(14;22)(q32;q11) has been reported in only 9 B-cell leukemia/lymphoma cases, but there has been no re-port about the clinical feature and prognosis of BCP-ALL with t(14;22)(q32;q11). In this paper, we describe the first pediatric case of BCP-ALL with t(14;22)(q32;q11) who presented with a very high white blood cell (WBC) count. He achieved cytogenetic complete remission after induction chemotherapy, and negative minimal residual disease (MRD) at the end of consolidation.
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KEYWORD
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Acute lymphoblastic leukemia, Chromosome aberrations, Child, Precursor cell lymphoblastic leukemia-lymphoma
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